“Production of medicines and vaccines for the treatment of dairy cows, cattle at Marphavet”

     Duc Hanh Marphavet veterinary pharmaceutical join stock company is a leading enterprise of manufacturing and trading of veterinary pharmacy, vaccines, animal feed, bio-products. Our company has experienced to the construction and development, the system of our group has driven the diversity to market segments. Due to the needs of this field as well as the direction of Agricultural and Rural Development Ministry, the economic integration requires enterprises which produce veterinary pharmacy and vaccines must be followed the standard manufacturing WHO, GMP of world health organization. 

I. Overview
      Animal husbandry is one of crucial economic fields in Viet Nam. Beside food supplying for human, animal husbandry can support farmers to increase their income, solve the problem of employment. However, this field has been meeting the difficulties such as the threat of diseases of livestock and poultry, informative demands of processes and technical husbandry veterinary pharmacy, vaccines that support farmers to produce and trade effectively. Beside the development of various economic fields, the dairy cows and cow husbandry has been focusing on the positive changes and gained remarkable achievements. For recent years, herd of cows in Viet Nam has been expanding and a number of cows in a herd have been also significantly increasing. Milk and beef are nutritious food and are essential demands of consumers. 

     Nowadays, milk consumption rate per person of Viet Nam annually is lower than the rate of 35 kg per person of Asia, thus demands and market of Viet Nam are still extremely high. In the integration of economy and market, the development of cow husbandry in Viet Nam is expected with a lot of potential and new opportunities. The implementation of decision 167 of Prime Minister for dairy cow development in period of 2001 to 2015, Vietnamese government has supported policies for dairy farmers. The projects of dairy cow breed via training programs supported to breeders for increasing their degree and technical breeding.

     Beside advantages, the dairy and cow husbandry fields have been meeting disadvantages: lack of experience, low productivity and low quality of milk, meat, small scale of husbandry, the formality of husbandry is spreading, the food is mainly saved so most of farmers do not have good conditions to apply advance science and technology to the development of husbandry. The tropical climate in Viet Nam is unsuitable for dairy cows husbandry, thus diseases are easily spread, epidemic status is occurring complicatedly and affects remarkably to cow husbandry field in particular and husbandry field in general. While the supervising works of diseases have not been incommensurate, diseases have been occurring more and more complicatedly, they are usually mixed and make difficulties in the processes of diagnosis and treatment. 

    Originated from the goal to increasing productivity of dairy cows, cows husbandry, implementation of veterinary works in treatment, prevention of diseases in cows, the expectation of qualified products for farmers, serving of milk and beef in Viet Nam, our company is equipped with modernly technical equipments to produce products that are national key and serve for animal husbandry field, increasing of economic productivity for Vietnamese resident. 

II. Chain, equipment and technology of drug and vaccine production
      Duc Hanh Marphavet veterinary pharmaceutical join stock company is a leading enterprise of manufacturing and trading of veterinary pharmacy, vaccine, animal food, bio-product. Our company has experienced on construction and development, the system of our group has driven diversity to market segments. Base on the needs of this field as well as the direction of Agricultural and Rural Development Ministry, economic integration requires enterprises which produce veterinary pharmacy and vaccine must be followed the manufacturing standard WHO, GMP of world health organization. 

      Marphavet company built a factory that constructed 3 chains: Injectable drug production, oral drug production, powdered drug production following the standards of GMP, GLP, GSP. Our factory reached total investment of 150 billion VND and was built on an area of 4.5 ha and equipped modern equipments, products which were produced in this factory based on advance automatic chains, materials were imported from reputable partners over the world such as USA, Bulgaria, Japan and were controlled, monitored tightly by modern equipments at examination centers which belong to our company. Our factory has produced annual average of 800.000 liters of injectable drugs, 1500.000 liters of oral drugs, 750 tons of powder antibiotics.

 

Ultrasonic bottle washing system


 

System of aeration fermentation– Germany 

       Nowadays, the development of animal husbandry field as well as the strict requirements of customers forward the usage of highly qualified, safe products, the reduction of labor and the cost of animal husbandry, we always apply the newest science advance s to pharmacy, supplement of materials that originated from nature, research and release highly qualified products, new generation, long acting reaction, safety without any residue is inside products.

     In animal husbandry, the prevention and administration of epidemic seems to be a key and obtains the first interest of Veterinary Medicine Department, Ministry of Agriculture and Rural Development, veterinary managers, farms. Nowadays in Viet Nam, the production of veterinary drugs by domestic companies has satisfied fully the requirements of this field. In addition, Viet Nam has basically been active of domestic drug resource, in which Marphavet company and subsidiary companies of BMG Group supplied an important part of veterinary pharmacy with high quality for husbandry field in Viet Nam. Although the control of epidemic has still met problem, in which the requirement of vaccine resource in prevention is essential. In 2014, Marphavet company was continuously expanding scale to build vaccine factory following the standard of GMP WHO which adapted more and more requirements of husbandry field.

      Our factory was designed and monitored with 3 chains, including viral vaccine production technology in embryo, viral vaccine following cell technology and bacterial vaccine production technology following aeration fermentation technology performance, modern manufacturing technologies and equipments were imported from well-known countries, such as BOSS, Germany, Italy that were evaluated by Department of Veterinary Medicine, Ministry of Agriculture and Rural Development as the most modern  chain in Viet Nam. Vaccine factory has already built and was conferred certificates of GMP, WHO by Ministry of Agriculture and Rural Development, all of systems were applied tightly and safely productive processes toward the standards of GMP, GLP, GSP, WHO, control system, total productive automatically system with  cleaning levels  E, D, C that were specialized, differential pressure ensures sterilized conditions following each stage of production, microorganism sources for the generation of antigen were inherited and transmitted to make sure about strains, serotypes that were the most popular in livestock and poultry diseases in Viet Nam.

       The material sources, biological enhancers that make glue, emulsion or lyophilizing and are imported from the most reputed brands in the world, such as Germany, France, America. Therefore, products would be the best quality and titer of antibody for the prevention of animal diseases. Beside conventional vaccines, our company has concentrated to study and produce products that are national key such as multivalent vaccine, one injection can be prevented multiple diseases, novel technology vaccines in the stage of integration economy should be an opportunity and a challenge also. Therefore, products that are high quality, stability and creativity would be powerful for the competition and integration. 

III. MANUFACTRING SITUATION OF PRODUCTS SERVED FOR CATTLE AND DAIRY COWS
        Our company is modernly equipped and gathered researcher specialists in Viet Nam, we are proud to be the first company that has provided product lines specialized for cattle, dairy cows and premix products that were combined with new generation of antibiotic following the most advanced technology in the world. The cattle and dairy cows husbandry have been facing to multiple epidemic that impact to the quality of meat, milk and caused the economic damage to farmers, typically dairy cow mastitis, inflammatory diseases of uteri, arthritis, parasites in blood, bronchitis, Pasteurellosis, diarrhea … Specialists of Marphavet studied particularly about conditions for animal husbandry in Viet Nam to provide suitable products from small and medium scales to large scale of farms. 

      The key of successful cattle producers relates to their knowledge about nutrient requirements, ratio of minerals, vitamins, essential amino acids… and the importance is the usage of drug must be safe for embryo and without the residue of antibiotic inside meat, milk. In fact, 98% of kinds of antibiotic has been residue and affected to the development of embryo, quantity and quality of milk. Marphavet company achieved 1.500 products, in which 20 in 400 products have been serving for treatment and supplement of dairy cows without any residue of antibiotic inside meat, milk. In particularly, injectable drugs are new generation of antibiotics that are combined with refined coconut oil and plant solvent, therefore they are absolutely safe for dairy cows and cattle, such as CEFQUINOM 150, CEFANEW-LA, MARCERTIUS NEW, FLU-INFLAMMATION, BACTAM, MARPHAMOX-LA, GLUCO-NAMIN, B12-BUTA MG.CA, MARTOSAL, ADE-MIX DAIRY COWS….

 

Cefquinom 150 product
 

      CEFQUINOM 150  contains the main component is Cefquinom Sulfate, a new generation of antibiotic that has broad spectrum, excipients are refined coconut oil and plant solvent that should be able to treat most of the diseases on beef and dairy cows without affecting to the quality of milk and meat, without existing of antibiotic, quality of milk is not be reduced, without sub-reaction and resistance of drug, safety and effectiveness to pregnant and lactating cows. CEFQUINOM 150 is a special treatment of dairy mastitis, metritis, pneumonia, asthma, pasteurellosis, paratyphoid, stamp, lepto, rotten nails, skin infection, E.coli swollen head, inflammatory bowel diarrhea ...

      CEFANEW-LA contains the main component is  Ceftiofur, pro-long affect within 72-96 hours, help for reducing of injection time, specializes for enteritis – diarrhea, E. coli, pneumonia, mastitis, metritis, secondary infectious diseases… in cattle, it is the first  pharmacy product in Viet Nam. This product is not only safe treatment for cattle and dairy cows but also effective treatment on livestock and poultry general. 

      Holding of modern equipments, advance technology and enthusiastic researcher specialists produced highlight products that gave the best prevention, treatment for animal diseases, maintained animal’s health, provided the fresh food resource for Vietnamese consumers.

Cited in “Conference of national product chain development served for Vietnamese milk and beef fields”